News archive of selected items
Current and past press releases as well as current and recent short notices
April 12, 2017
Two new publications regarding PBPK modeling! : A pregnancy PBPK model has been developed, and evaluated for renally cleared drugs.
October 18, 2016
Published in CPT Pharmacometrics & Systems Pharmacology: Applied Concepts in PBPK modeling: How to build a PBPK/PD model
September 15, 2016
New Version Release: Computational Systems Biology Software Suite Version 6.3
We are proud to present the new SB Suite Version 6.3 which is available for download here. The new release includes calculation of time profile confidence intervals and sensitivity analysis of...
June 20, 2016
New Version Release: Computational Systems Biology Software Suite Version 6.2
We are proud to present the new SB Suite Version 6.2 which is available for download here. The new release includes a fully integrated Parameter Identification Toolbox, which is directly accessible...
April 01, 2016
New Version Release: Computational Systems Biology Software Suite Version 6.1
We are proud to present the new SB Suite Version 6.1 which is available for download here. The new release features some new functions for oral absorption as well as new compound templates and...
November 19, 2015
Published in Transactions on Biomedical Engineering: Robust PBPK/PD based Model Predictive Control of Blood Glucose.
October 20, 2015
New Version Release: Computational Systems Biology Software Suite Version 6
Major usability improvements in PK-Sim and MoBi: New working journal function, comparison of simulations/building blocks, favorites, new chart editor functions, SBML import.
August 12, 2015
Workshop: Academic User Workshop 2015
Our Academic User Workshop 2015 is now open for registration!
May 27, 2015
Published in BJCP: Contribution of rivaroxaban to the international normalized ratio when switching to warfarin for anticoagulation as determined by simulation studies
Br J Clin Pharmacol. 2015 Jun;79(6):959-66. doi: 10.1111/bcp.12571.
May 11, 2015
New Release: Computational Systems Biology Software Suite Version 5.6.3 (Kopie 1)
Drug-Drug-Interaction, pre-configured substance models and Liver Zonation in PK-Sim
January 16, 2015
New Release: Computational Systems Biology Software Suite Version 5.5.3
MoBi: Usability improvements and several new features
September 02, 2014
New Release: Computational Systems Biology Software Suite Version 5.4.3
Bug fix release and further improvement of observed data handling, focus on population toolbox
July 28, 2014
New Release: Computational Systems Biology Software Suite Version 5.4.1
Major redesign of observed data handling
June 16, 2014
New Release: Computational Systems Biology Software Suite Version 5.3.2
Bug Fix Release
April 30, 2014
New Release: Computational Systems Biology Software Suite Version 5.3.1
New feature – Population simulation integrated into PK-Sim: Virtual population and paediatric studies made substantially easier
January 30, 2014
New Release: Computational Systems Biology Software Suite Version 5.2.2
Bug Fix Release 5.2.2
October 22, 2013
New Release: Computational Systems Biology Software Suite Version 5.2
New Release with several new features and improvements
August 15, 2013
Published: A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System
August 12, 2013
Published: Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban
May 23, 2013
Published: Utilizing in vitro and PBPK tools to link ADME characteristics to plasma profiles
April 12, 2013
Published - Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.
The Article by Markus Krauss, Rolf Burghaus, Jörg Lippert, Mikko Niemi, Pertti Neuvonen, Andreas Schuppert, Stefan Willmann, Lars Kuepfer and Linus Görlitz was published in In Silico Pharmacology...
April 12, 2013
New Release: Computational Systems Biology Software Suite V5.1.5
The Bug Fix Release 5.1.5 of the Systems Biology Software Suite addresses issues related to wrong calculations of AUCs and t1/2 under certain circumstances. This has been corrected in the underlying...
February 06, 2013
New Release: Computational Systems Biology Software Suite V5.1.4
The BTS Computational Systems Biology Software Suite release version 5.1.4 removes a bug causing problems with population simulations varying gastric emptying time. To download the setup, please...
December 18, 2012
Featured in “Nature Chemical Biology”
“Integrating Cellular Metabolism into a Multiscale Whole-Body Model” by Krauss et al. was featured in the “Research Highlights” section of “Nature Chemical Biology”: ...
December 17, 2012
New Release: Computational Systems Biology Software Suite V5.1.3
The Bug Fix Release 5.1.3 of the Systems Biology Software Suite has several bugs fixed and a list of small feature improvements such as introducing the possibility to “clone” simulations. The updated...
October 31, 2012
Published - title story in PLOS Comp Bio: Integrating Cellular Metabolism into a Multiscale Whole-Body Model.
February 13, 2012
Published: First dose in children - physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development
October 14, 2011
Published: Quantifying stability in gene list ranking across microarray derived clinical biomarkers
October 14, 2011
Published: Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions
June 19, 2011
Let’s Make a Model: Opinions and impressions on our work
With its Systems Biology & Computational Solutions global competence center, Bayer Technology Services helps customers better plan their clinical trials ...
May 19, 2011
Prof. Dr. Schuppert of BTS Spokesperson of newly founded Network for mathematical modeling, simulation and optimization
New BMBF based expert committee at the University of Heidelberg
April 29, 2011
Published: Statistical Analysis of Chemical Transformation Kinetics Using Markov-Chain Monte Carlo Methods
April 26, 2011
Published: Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation
April 05, 2011
New compartmental Gastro-Intestinal Model
New GI-Model will be part of PK-Sim 5.0 - get some pre-release information.
March 01, 2011
All new Software Suite with PK-Sim 5 and MoBi 3 due to be released in Summer 2011
Fully redesigned Computational Systems Biology Software Suite
» More
February 08, 2011
Published: A computational systems biology software platform for multiscale modeling and simulation
Integrating whole-body physiology, disease biology, and molecular reaction networks
December 15, 2010
Workshop Announcement for ACoP 2011
Pre- and post-meeting workshops on mechanistic multiscale modeling from whole-body pharmacokinetics and disease biology to molecular reaction networks
September 23, 2010
PK-Sim® Express – Direct integration of gene expression data into PBPK models with PK-Sim®
Computational Systems Biology experts at Bayer Technology Services have developed a new concept for directly integrating tissue specific expression data into physiologically-based pharmacokinetic...
» More
September 07, 2010
Published in MSB: Towards whole-body systems physiology
News and Views Contribution