MoBi®

MoBi^® is a sophisticated, flexible software package for mechanistic and dynamic modeling of biological processes and drug action. It is completely integrated with PK-Sim^® [our package for physiologically-based pharmacokinetics (PBPK) modeling] and is, consequently, especially suited for the analysis of complex pharmacokinetic and pharmacodynamic models under simultaneous consideration of whole-body physiology.

Modeling with MoBi^® is a unique means to integrate in vitro and in vivo findings into one unified representation allowing for the evaluation, analysis, interpretation and prediction of experiments to an utmost level of detail. MoBi^® facilitates the process of model building and simulation of biochemical reaction networks with its intuitive graphical user interface, the import and export to other modeling languages (e.g. SCAMP) and a powerful visualization tool for simulation results.

The integration of MoBi^® and MATLAB^®, particularly the recently developed MoBi^® Toolbox for MATLAB^®, allows for the seamless performance of complex optimizations and sensitivity analyses as well as the implementation of large, highly sophisticated simulation and analysis tasks that can be programmed to run in an automated way.

PBPK model and time course of a drug and one of its metabolites.

Biochemical reaction network model.