PK-Sim®

PK-Sim^® is a unique software tool for summary and evaluation of preclinical and clinical experimental results on absorption, distribution, metabolism and excretion (ADME) by means of whole-body physiologically-based pharmacokinetic (PBPK) modeling and simulation. Features, available Packages and integrated Modules as well as information on all previous and current PK-Sim^® Releases. You can also get informed about the System Requirements for operating our software packages.

It allows for straightforward construction of highly specific physiologically-based PK models by incorporation of in-vitro and in-vivo experimental data gathered in preclinical and clinical phases and, thereby, to develop a consistent mechanistic understanding of the key processes driving pharmacokinetics.

The resulting PK model allows to extrapolate to various scenarios such as, e.g. new application routes or schemes, new formulations, special populations, etc. and, thereby, to support the preparation of study design of succeeding preclinical and clinical experiments. Finally, the new quality of mechanstic understanding of pharmacokinetics can serve as an additional input for competent go/no-go decision making.

On the following pages, you can find detailed information on PK-Sim^®