PK-Sim®

The comprehensive software tool for whole-body physiologically based pharmacokinetic (WB-PBPK) modeling and simulation.

PK-Sim^® is a unique software tool for summary and evaluation of preclinical and clinical experimental results on absorption, distribution, metabolism and excretion (ADME) by means of whole-body physiologically-based pharmacokinetic (PBPK) modeling and simulation.

It allows the straight forward construction of highly specific physiologically-based PK models by incorporation of in-vitro and in-vivo experimental data gathered in preclinical and clinical phases and, thereby, to develop a consistent mechanistic understanding of the key processes driving pharmacokinetics.

The resulting PK model allows to extrapolate to various scenarios such as, e.g. new application routes or schemes, new formulations, special populations, etc. and, thereby, to support the preparation of study design of succeeding preclinical and clinical experiments. Finally, the new quality of mechanstic understanding of pharmacokinetics can serve as an additional input for competent go/no-go decision making.

Example screenshots giving an overview on the programm window (left) and species tab (right).