PK-Sim® Releases

Improvements and enhanced features of PK-Sim^®

What is New in PK-Sim^® 4.2

1. PBPK modeling and simulation of macromolecules, such as therapeutic proteins, is now possible due to the newly developed two-pore model
2. New Species - Beagle dog.
3. Refinement of model for peripheral sampling

To see a detailed list of all newly available features in PK-Sim® 4.2 just click here. 

What’s New in PK-Sim^® 4.1

1. Additional Model Structure for a Better Description of Special  Molecule Classes
2. Switch of Species and New Concept “Specific Clearance”
3. Scaling of Vmax values
4. New Units for in vitro Data to Determine Enzyme Kinetics
5. Calculation of Intestinal Permeability from in-vitro Data
6. Additional Calculation Methods for Plasma/Organ Partition Coefficients
   • Schmitt Model
   • Poulin & Theil Model
   • Berezhkovskiy Model
7. New Species – Minipig
8. New Compartment in Human Model - Saliva
9. New Application Routes
   • Subcutaneous 
   • Dermal
10. Reorganization of Graphical User Interface
11. Summary Plots
12. Project Report
13. Redesign of Compound Window
14. Minor Improvements

To see a detailed list of all newly available features in PK-Sim® 4.1 just click here.

What’s new in PK-Sim^® 4.0.2

1. CYP2C19, CYP2C9, CYP2C8 and CYP2B6 have been added to the Clearance Scaling Module.
2. Minor bug fixes.

Download Update [11.5 MB]

What’s new in PK-Sim^® 4.0.1

1. Calculation of organ/plasma partitioning coefficients according to the methods of Rodgers and Rowland (Rodgers and Rowland, 2007) or, optionally, according to the PK-Sim^® standard method.
2. New internal model structure allowing the incorporation of custom PBPK models.
3. Quicker loading and saving of project files.

What’s new in PK-Sim^® 3.1.2

1.  Minor bug fixes.

Download Update

What’s new in PK-Sim^® 3.1.1

1. Asian Population (Tanaka, 1996) was added to the PK-Sim^® population data base.
2. PK-Sim^®  now works with OS set to non-latin typesets (e.g. Japanese).
3. Export of PK-Sim^® simulations to our new modeling and simulation tool for biological systems MoBi^®.  

What’s new in PK-Sim^® 3.0.6

1. Minor bug fixes.

What’s new in PK-Sim^® 3.0.5

1. The new Statistics Tab allows the user to easily generate bias (+ 95% Confidence Intervals) and precision values to quantitatively compare a simulated curve to observed data. A linear regression analysis can also be performed for the simulated vs. observed data.

What’s new in PK-Sim^® 3.0.4

1. The monkey is now included as an additional species.
2. Minor bug fixes.

What’s new in PK-Sim^® 3.0.2

1. Global options are now saved per user.
2. Concentration unit saved for each plot window separately.
3. Fraction unbound will be updated after loading a compound from the master or project database.
4. Possible problems while loading projects are fixed.
5. User defined settings for distribution parameters saved for use in PK-Pop simulations.
6. Minor bug fixes.

What’s new in PK-Sim^® 3.0.1

1. Clearance Scaling in Children: A clearance scaling module that calculates age dependent clearance in children based on the known adult clearance value and the proportions of eliminating mechanisms involved has been implemented as an add on module in PK-Sim^®.
2. pH Dependent Solubility: Solubility vs. pH is now calculated by PK-Sim^® based on pKa values of multiple acidic or basic groups. The solubility vs. pH table can further be edited to make use of existing experimental data.
3. New Dissolution Module: The new dissolution module calculates the dissolution dynamic of a sold particle formulation moving down the GI tract and is dependent on the particle size distribution and pH-dependent solubility. Different options, such as how the precipitated drug material is treated, are available.
4. Flexible Administration: The compound can be administered by pre-defined uptake functions (zero- and 1st-order) as well as arbitrary source functions in the form of user-defined mass-time tables into any (sub-)compartment of the model. This flexible administration scheme can be used to model dermal, inhalation, parenteral and other types of administration.
5. Output of Percentage Metabolized: The fraction of the administered dose metabolized is calculated as additional output. This information is available for each specified metabolic process. It is now possible to model metabolite kinetics in a separate PK-Sim^® simulation by inputting the time course of metabolite formation within the (sub)-compartment where metabolism occurs.
6. Re-Organization of the Graphical User Interface (GUI): The GUI has been re-structured in an even more intuitive manner. The simulation parameters are now organized into four categories: Species, Absorption, Distribution, and Metabolism & Excretion. The input forms for active transporters and metabolism are dynamic and offer more flexibility with respect to the number and type of active process.
7. Read-Only Mode: PK-Sim^® V3.0 can be run in a read-only mode when no valid license is present. The read-only mode provides full access to all previously generated PK-Sim^® projects and output data, but does not allow for parameter changes or simulations to be run.
8. PK-Sim^® Absorption Package: A new basis package of PK-Sim^® has been released. The Absorption package simulates the gastro-intestinal transit and absorption process and serves the needs of scientists involved in biopharmaceutics and formulation development.