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... here. The new release includes a fully integrated Parameter Identification Toolbox, which is directly accessible in PK-Sim and ... multiple simulations or to link multiple simulation parameters to one identification parameter. For a more detailed list of new features and ... View

... here. The new release includes a fully integrated Parameter Identification Toolbox, which is directly accessible in PK-Sim and ... multiple simulations or to link multiple simulation parameters to one identification parameter. For a more detailed list of new features and ... View

Features

Weight/Frequency 76%

... "Reaction", "Event“, “Observer“, "Start Values“ (for parameters or molecules) are set up as separate and re-usable ... groups of molecules instead of for one molecule only. Parameters can be defined as constant; either by formula, by ... even as state variable (function of time). Constant parameters of the spatial structure can become "distributed Features

Releases

Weight/Frequency 75%

... of time profile confidence intervals as output of parameter identification. Three different types of confidence intervals are ... error, which is based on the uncertainty of estimated parameters. This uncertainty is based on an estimation of the ... predictions.                      Sensitivity of PK- Releases

... 23-26, Seattle, WA, USA Post-Meeting Workshop on "Parameter plausibility assessment for small and large molecule PBPK models applied to specific populations". Parameter plausibility assessment for small and large molecule ...   Fee: $600/Industry $300/Academia Register here   Parameter estimation and sensitivity analysis are major ... of PBPK models. Ideally, identifiability of Details

... 23-26, Seattle, WA, USA Post-Meeting Workshop on "Parameter plausibility assessment for small and large molecule PBPK models applied to specific populations". Parameter plausibility assessment for small and large molecule ...   Fee: $600/Industry $300/Academia Register here   Parameter estimation and sensitivity analysis are major ... of PBPK models. Ideally, identifiability of Details

Workshop Page 2017 Registration

Weight/Frequency 67%

... in PK-Sim ® and MoBi ® . A detailed introduction to parameter identification will be part of this session. We will wrap up the day ... 5: Advanced PBPK/PD modeling - Customizing models, parameter identification and sensitivity analysis Application examples: - Identification and optimization of Workshop Page 2017 Registration

... PK-Sim® simplifies physiologically-based pharmacokinetic (PBPK) modeling by setting all essential model variables on the basis of input parameters that can be easily determined experimentally. With MoBi, multiple models generated with PK-Sim® can be coupled to form a complex ... at the site of action. The products and services available from BTS support all stages of the drug research and development process – from the View

... PK-Sim® simplifies physiologically-based pharmacokinetic (PBPK) modeling by setting all essential model variables on the basis of input parameters that can be easily determined experimentally. With MoBi, multiple models generated with PK-Sim® can be coupled to form a complex ... at the site of action. The products and services available from BTS support all stages of the drug research and development process – from the View

Features

Weight/Frequency 65%

... the goal of being fully transparent in regards to parameters and functions used within PK-Sim, all are made ... in an unprecedentedly convenient fashion . Advanced Parameter Identification (PI) Toolbox A fully integrated PI Toolbox provides a straightforward means to adjust key parameters of your PBPK models automatically within ... you full control and direct feedback whether the Features

April 12, 2017

Two new publications regarding PBPK modeling! : A pregnancy PBPK model has been developed, and evaluated for renally cleared drugs.

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March 28, 2017

Published in npj Systems Biology and Applications: Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

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December 19, 2016

New publications regarding PBPK modeling: Elderly, Isoniazid, DDI and Diabetes. In addition: A white paper regarding good practices in drug discovery and development

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October 14, 2017

ACoP8 Conference, October 15-18 2017 in Florida

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June 25, 2017

14th European ISSX Meeting, June 26-29 2017 in Cologne

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June 05, 2017

PAGE Meeting 2017, June 06-09, Budapest, Hungary

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